Excitatory Amino Acid Transporters (EAAT), formerly known as Glutamate transporters, belong to the family of neurotransmitter transporters. They serve to terminate the excitatory neurotransmitter signal by removal (uptake) of glutamate from the neuronal synapse into Glia cells.
In details, the EAATs are membrane-bound pumps that resemble ion channels. These transporters play the important role of regulating concentrations of glutamate in the extracellular space, keeping it at low levels.After glutamate is released as the result of an action potential, glutamate transporters quickly remove it from the extracellular space to keep its levels low, thereby terminating the synaptic transmission.
Without the activity of glutamate transporters, glutamate would build up and kill cells in a process called excitotoxicity, in which excessive amounts of glutamate acts as a toxin to neurons by triggering a number of biochemical cascades. The activity of glutamate transporters also allows glutamate to be recycled for repeated release.
Glutamate transporters are also present in many other tissues such as bone and testes. Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.