Mitochondrial fusion may regulate mitochondrial morphogenesis and underlie complementation between mitochondrial genomes in mammalian cells. Mitochondrial dysfunction is a major cause of neuronal death in degenerative disorders, such as Parkinson’s disease, and can be triggered by an imbalance in the dynamic equilibrium between mitochondrial fission and fusion. MFN1 (mitofusin 1) and MFN2 (mitofusin 2) are nuclear encoded mitochondrial proteins. MFN1 is an essential transmembrane GTPase and appears to be a key player in mediating mitochondrial fusion and morphology in mammalian cells.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.