Anti-E7 protein(Human papillomavirus type 16)
Infection with human papillomavirus type 16 (HPV-16) is the main factor associated with development of cervical cancer . The HPV-16 E6 and E7 proteins are constitutively produced in cervical carcinomas, and E7 was shown to interact with several cell compounds, causing deregulation of the cell cycle and cell transformation . E7 is a 98-amino-acid nuclear phosphoprotein that is devoid of any known enzymatic activity . In eukaryotic cells, E7's half-life is short (30 to 40 min); its degradation is mediated by the ubiquitin-proteasome pathway . E7 protein is widely studied because of its implication in carcinoma onset. It is also considered to be a good antigen candidate for the development of new vaccines against cervical cancer.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.