Storage Instruction:Store the kit at 4°C. Description:
C-Peptide originate as a single polypeptide chain known as proinsulin(MW 9000) in the pancreatic cell. Proinsulin is cleaved proteolytically to form equimolar amounts of mature insulin and C-Peptide that are released into the portal vein. So called because it connects the A and B chains of insulin in the proinsulin molecule. C-Peptide is a single chain of 31 amino acid (MW 30,200). Unlike insulin has no known physiological function. Urine concentrations of C-Peptide are 20-50 times higher than in plasma, unlike plasma insulin levels, which fluctuate in response to meals, measurement of the 24 hour urinary excretion of C-Peptide provides a useful monitor of average cell insulin secretion 2. C-Peptide measurements are useful in insulinoma diagnosis, especially in patients treated with insulin. Elevated C-Peptide levels are indicative of insulinoma. C-Peptide measurements are useful in the need for progression to insulin therapy in non-insulin dependent diabetics (NIDDM).