Storage Instruction:Store the kit at 4°C. Description:
The vascular endothelial growth factor (VEGF) family of proteins is important for the development of blood vessels during embryogenesis and in pathological conditions such as tumorigenesis (see reference 1 for a review).VEGF (VEGF-A) is a homodimeric,
heparin-binding glycoprotein with potent angiogenic, mitogenic and vascular permeability-enhancing activities specific for endothelial cells.
VEGF-D (also known as c-fos-induced growth factor or FIGF(4))is most closely related to VEGF-C. It shares structural homology and receptor specificity with VEGF-C, thus suggesting that VEGF-C and VEGF-D represent a subfamily of the VEGFs.VEGF-D is
initially synthesized as a precursor protein containing unique N- and C-terminal propeptides in addition to a central receptor-binding VEGF homology domain (VHD). The N- and C-terminal propeptides are not found within other VEGF family members.These propeptides are proteolytically cleaved during biosynthesis to generate a mature, secreted form consisting of noncovalent dimers of the VHD.