Storage Instruction:Store the kit at 4°C. Description:
PECAM-1 (platelet endothelial cell adhesion molecule-1) also called CD31 and EndoCAM is a newly characterized adhesion molecule that belongs to the immunoglobulin superfamily . PECAM-1 is a transmembrane glycoprotein with a molecular weight of approximately 130 kDa, depending on the degree of glycosylation .
PECAM-1 is constitutively expressed on all vascular cells and has provided a useful immunohistochemical marker of blood vessels, particularly in the setting of angiogenesis. It has also been found on platelets, monocytes, neutrophils and CD8+ T cells. Bone marrow stem cells and transformed cell lines of the myeloid and megakaryocytic lineage also express PECAM-1 . Interestingly, PECAM-1 was also detected on human, mouse and rat solid tumor lines.