Introduction of Cinnarizine
Cinnarizine (Stugeron, Stunarone) is an antihistamine which is mainly used for the control of nausea and vomiting due to motion sickness. Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955. It is not available in the United States or Canada.
It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perception.
Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. It is also effectively combined with other nootropics, primarily Piracetam; in such combination each drug potentiate the other in boosting brain oxygen supply.
While this may be true, cinnarizine is also known to cause acute and chronic parkinsonism probably due to its affinity for D2 receptors, which strongly countersuggests its actual usefulness for improving neurohealth.
Cinnarizine can be used in scuba divers without an increased risk of central nervous system oxygen toxicity.
Cinnarizine can cause drowsiness and blurred vision. It is important that users make sure their reactions are normal before driving, operating machinery, or doing any other jobs which could be dangerous if they are not fully alert or able to see well.The CAS No. is 298-57-7;Molecular Formula is C26H28N2;Formula Weight is 368.52.It should be sealed to preserve in dry and dark place.